6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylicaci
6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS: 912773-22-9
Molecular Formula: C7H4BrN3O2
6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylicaci - Names and Identifiers
| Name | 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid |
| Synonyms | 6-Bromo-pyrazolo[1,5-a]py... 6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylicaci 6-bromo-3-pyrazolo[1,5-a]pyrimidinecarboxylic acid 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid |
| CAS | 912773-22-9 |
| InChI | InChI=1S/C7H4BrN3O2/c8-4-1-9-6-5(7(12)13)2-10-11(6)3-4/h1-3H,(H,12,13) |
6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylicaci - Physico-chemical Properties
| Molecular Formula | C7H4BrN3O2 |
| Molar Mass | 242.03 |
| Density | 2.09±0.1 g/cm3(Predicted) |
| pKa | -0.21±0.41(Predicted) |
| Storage Condition | 2-8℃ |
6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylicaci - Introduction
6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is an organic compound with the chemical formula C7H4BrN3O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Melting point: 230-235°C
-Solubility: Soluble in some organic solvents (such as alcohols, ethers, esters, chlorinated hydrocarbons, etc.), slightly soluble in water
Use:
- 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is commonly used as an intermediate in organic synthesis. It can be used as a raw material for drug synthesis or other organic synthesis reactions.
-It can also be used to prepare various biologically active compounds, such as drugs, pesticides, dyes, etc.
Method:
6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is generally prepared by chemical reaction synthesis, and the following steps are commonly used in the laboratory:
1. Mix the brominated pyrimidine (bromopyrimidine) with distilled water and heat to 40-55°C, and stir until the pyrimidine bromide is completely dissolved.
2. Sulfonamide (sulfonamide) is added to the solution and the reaction is stirred for 6-8 hours.
3. Cool to room temperature and add dilute acid solution to acidify and precipitate.
4. After filtration, washing and drying, pure 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is obtained.
Safety Information:
- 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid should be handled and stored to avoid contact with skin and eyes.
-It may be irritating to the skin and eyes, so appropriate protective measures should be used, such as wearing gloves and goggles.
-Avoid inhaling the dust of the compound during operation, so it is necessary to operate in a well-ventilated place.
-When disposing of waste, local waste management regulations and standard disposal methods should be followed.
Before conducting any experiments, please read the chemical safety data sheet and material safety data sheet carefully, and follow the correct operation and handling procedures.
Nature:
-Appearance: White crystalline solid
-Melting point: 230-235°C
-Solubility: Soluble in some organic solvents (such as alcohols, ethers, esters, chlorinated hydrocarbons, etc.), slightly soluble in water
Use:
- 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is commonly used as an intermediate in organic synthesis. It can be used as a raw material for drug synthesis or other organic synthesis reactions.
-It can also be used to prepare various biologically active compounds, such as drugs, pesticides, dyes, etc.
Method:
6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is generally prepared by chemical reaction synthesis, and the following steps are commonly used in the laboratory:
1. Mix the brominated pyrimidine (bromopyrimidine) with distilled water and heat to 40-55°C, and stir until the pyrimidine bromide is completely dissolved.
2. Sulfonamide (sulfonamide) is added to the solution and the reaction is stirred for 6-8 hours.
3. Cool to room temperature and add dilute acid solution to acidify and precipitate.
4. After filtration, washing and drying, pure 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid is obtained.
Safety Information:
- 6-Bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid should be handled and stored to avoid contact with skin and eyes.
-It may be irritating to the skin and eyes, so appropriate protective measures should be used, such as wearing gloves and goggles.
-Avoid inhaling the dust of the compound during operation, so it is necessary to operate in a well-ventilated place.
-When disposing of waste, local waste management regulations and standard disposal methods should be followed.
Before conducting any experiments, please read the chemical safety data sheet and material safety data sheet carefully, and follow the correct operation and handling procedures.
Last Update：2024-04-09 20:49:11
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